This report provides a high-level overview of the tobacco sector in Malawi. It opens with a brief description of large-scale changes in global tobacco production and their implications for Malawi, a key focus for the Foundation for a Smoke-Free World’s Agricultural Transformation Initiative. Then the report examines the lived experiences of smallholder tobacco farmers with an emphasis on their economic well-being, health, and environment. It then pivots to summarizing the in-country landscape in which a transition to alternative livelihoods must potentially take place. In doing so, the profile simultaneously seeks to make a case for change while providing a multifaceted contextual window into the country’s economic, agricultural, regulatory, operational, and political profile with a focus on the tobacco sector at large.