The purpose of the Foundation for a Smoke-Free World is to improve global health by ending smoking in this generation, while mitigating the effects of this transformation on tobacco farmers and tobacco-dependent economies. The Foundation’s Strategic Plan is supported by three core initiatives: Health, Science, and Technology; Agriculture and Livelihoods; and Industry Transformation. All three initiatives naturally intersect with several of the SDGs. The SDGs thus provide a valuable framework to assess the coherency and interdependence of the Foundation’s core initiatives.