The Global Trends in Nicotine reports establish the groundwork for the Foundation for a SmokeFree World in the area of industry transformation, and represent an important component in the Foundation’s research program. Specifically, the reports identify the major players in nicotine delivery, outline their product offerings and geographic focus, and quantify their output. The first Global Trends in Nicotine report was published based on data from 2017. This report updates the record with data from 2020.